Integrating nested PCR with high-throughput sequencing to characterize mutations of HBV genome in low viral load samples

Due to the low viral load of hepatitis B virus (HBV) in plasma samples, conventional techniques have limitations to the detection of antiviral resistance mutations. To solve the problem, we developed a fast, highly sensitive, and accurate method to sequence the HBV whole-genome sequencing in plasma...

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Detalles Bibliográficos
Autores principales: Wang, Xianjun, Xu, Lihui, Chen, Yueming, Liu, Anbing, Wang, Liqian, Xu, Peisong, Liu, Yunhui, Li, Lei, Meng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
4500
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627833/
https://www.ncbi.nlm.nih.gov/pubmed/28746207
http://dx.doi.org/10.1097/MD.0000000000007588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627833/
https://www.ncbi.nlm.nih.gov/pubmed/28746207
http://dx.doi.org/10.1097/MD.0000000000007588

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