Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD(+)-binding site

Sirtuin 2 (SIRT2), a member of the NAD(+)-dependent histone deacetylase family, has recently received increasing attention due to its potential involvement in neurodegenerative diseases and the progression of cancer. Potent and selective SIRT2 inhibitors thus represent desirable biological probes. B...

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Detalles Bibliográficos
Autores principales: Mellini, Paolo, Itoh, Yukihiro, Tsumoto, Hiroki, Li, Ying, Suzuki, Miki, Tokuda, Natsuko, Kakizawa, Taeko, Miura, Yuri, Takeuchi, Jun, Lahtela-Kakkonen, Maija, Suzuki, Takayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628579/
https://www.ncbi.nlm.nih.gov/pubmed/28989670
http://dx.doi.org/10.1039/c7sc02738a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628579/
https://www.ncbi.nlm.nih.gov/pubmed/28989670
http://dx.doi.org/10.1039/c7sc02738a

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