Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme

The CTX-M family of beta lactamases mediate broad-spectrum antibiotic resistance and are present in the majority of drug-resistant Gram-negative bacterial infections worldwide. Allosteric mutations that increase catalytic rates of these drug resistance enzymes have been identified in clinical isolat...

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Detalles Bibliográficos
Autores principales: Latallo, M. J., Cortina, G. A., Faham, S., Nakamoto, R. K., Kasson, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628580/
https://www.ncbi.nlm.nih.gov/pubmed/28989673
http://dx.doi.org/10.1039/c7sc02676e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628580/
https://www.ncbi.nlm.nih.gov/pubmed/28989673
http://dx.doi.org/10.1039/c7sc02676e

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