Neutral evolution of drug resistant colorectal cancer cell populations is independent of their KRAS status

Emergence of tumor resistance to an anti-cancer therapy directed against a putative target raises several questions including: (1) do mutations in the target/pathway confer resistance? (2) Are these mutations pre-existing? (3) What is the relative fitness of cells with/without the mutation? We addre...

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Detalles Bibliográficos
Autores principales: Blagoev, Krastan B., Wilkerson, Julia, Burotto, Mauricio, Kim, Chul, Espinal-Domínguez, Edward, García-Alfonso, Pilar, Alimchandani, Meghna, Miettinen, Markku, Blanco-Codesido, Montserrat, Fojo, Tito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628783/
https://www.ncbi.nlm.nih.gov/pubmed/28981524
http://dx.doi.org/10.1371/journal.pone.0175484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628783/
https://www.ncbi.nlm.nih.gov/pubmed/28981524
http://dx.doi.org/10.1371/journal.pone.0175484

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