HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been di...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Fang, Zhao, Qiong, Sheraz, Muhammad, Cheng, Junjun, Qi, Yonghe, Su, Qing, Cuconati, Andrea, Wei, Lai, Du, Yanming, Li, Wenhui, Chang, Jinhong, Guo, Ju-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629035/
https://www.ncbi.nlm.nih.gov/pubmed/28945802
http://dx.doi.org/10.1371/journal.ppat.1006658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629035/
https://www.ncbi.nlm.nih.gov/pubmed/28945802
http://dx.doi.org/10.1371/journal.ppat.1006658

Ejemplares similares