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HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been di...

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Detalles Bibliográficos
Autores principales:	Guo, Fang, Zhao, Qiong, Sheraz, Muhammad, Cheng, Junjun, Qi, Yonghe, Su, Qing, Cuconati, Andrea, Wei, Lai, Du, Yanming, Li, Wenhui, Chang, Jinhong, Guo, Ju-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629035/ https://www.ncbi.nlm.nih.gov/pubmed/28945802 http://dx.doi.org/10.1371/journal.ppat.1006658

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