Enhanced unbiased sampling of protein dynamics using evolutionary coupling information

One of the major challenges in atomistic simulations of proteins is efficient sampling of pathways associated with rare conformational transitions. Recent developments in statistical methods for computation of direct evolutionary couplings between amino acids within and across polypeptide chains hav...

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Detalles Bibliográficos
Autores principales: Shamsi, Zahra, Moffett, Alexander S., Shukla, Diwakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629199/
https://www.ncbi.nlm.nih.gov/pubmed/28983093
http://dx.doi.org/10.1038/s41598-017-12874-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629199/
https://www.ncbi.nlm.nih.gov/pubmed/28983093
http://dx.doi.org/10.1038/s41598-017-12874-7

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