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APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovere...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629363/ https://www.ncbi.nlm.nih.gov/pubmed/28260788 http://dx.doi.org/10.1038/leu.2017.75 |