APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovere...

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Detalles Bibliográficos
Autores principales: Li, Z, Abraham, B J, Berezovskaya, A, Farah, N, Liu, Y, Leon, T, Fielding, A, Tan, S H, Sanda, T, Weintraub, A S, Li, B, Shen, S, Zhang, J, Mansour, M R, Young, R A, Look, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629363/
https://www.ncbi.nlm.nih.gov/pubmed/28260788
http://dx.doi.org/10.1038/leu.2017.75

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