ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis. Metabolic alterations have been involved in tumor progression and attracted interest as a target fo...

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Detalles Bibliográficos
Autores principales: Ju, H-Q, Zhan, G, Huang, A, Sun, Y, Wen, S, Yang, J, Lu, W-h, Xu, R-h, Li, J, Li, Y, Garcia-Manero, G, Huang, P, Hu, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629368/
https://www.ncbi.nlm.nih.gov/pubmed/28194038
http://dx.doi.org/10.1038/leu.2017.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629368/
https://www.ncbi.nlm.nih.gov/pubmed/28194038
http://dx.doi.org/10.1038/leu.2017.45

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