O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies

The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression a...

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Detalles Bibliográficos
Autores principales: Freund, P, Kerenyi, M A, Hager, M, Wagner, T, Wingelhofer, B, Pham, H T T, Elabd, M, Han, X, Valent, P, Gouilleux, F, Sexl, V, Krämer, O H, Groner, B, Moriggl, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629373/
https://www.ncbi.nlm.nih.gov/pubmed/28074064
http://dx.doi.org/10.1038/leu.2017.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629373/
https://www.ncbi.nlm.nih.gov/pubmed/28074064
http://dx.doi.org/10.1038/leu.2017.4

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