Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

Background: 1,2,3,4-Tetrahydroisoquinolines (THIQs) are common motifs in alkaloids and in medicinal chemistry. Synthetic access to THIQs via the Pomeranz–Fritsch–Bobbit (PFB) methodology using mineral acids for deactivated, electron-poor aromatic systems, is scarcely represented in the literature. H...

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Detalles Bibliográficos
Autores principales: Mottinelli, Marco, Leese, Mathew P, Potter, Barry V L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629393/
https://www.ncbi.nlm.nih.gov/pubmed/29062406
http://dx.doi.org/10.3762/bjoc.13.182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629393/
https://www.ncbi.nlm.nih.gov/pubmed/29062406
http://dx.doi.org/10.3762/bjoc.13.182

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