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Robust mutant strain design by pessimistic optimization
BACKGROUND: Flux Balance Analysis (FBA) based mathematical modeling enables in silico prediction of systems behavior for genome-scale metabolic networks. Computational methods have been derived in the FBA framework to solve bi-level optimization for deriving “optimal” mutant microbial strains with t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629566/ https://www.ncbi.nlm.nih.gov/pubmed/28984191 http://dx.doi.org/10.1186/s12864-017-4025-7 |