Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity

The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the TP53 gene, while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactivation of its endogenous repres...

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Detalles Bibliográficos
Autores principales: Andrysik, Zdenek, Galbraith, Matthew D., Guarnieri, Anna L., Zaccara, Sara, Sullivan, Kelly D., Pandey, Ahwan, MacBeth, Morgan, Inga, Alberto, Espinosa, Joaquín M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630028/
https://www.ncbi.nlm.nih.gov/pubmed/28904012
http://dx.doi.org/10.1101/gr.220533.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630028/
https://www.ncbi.nlm.nih.gov/pubmed/28904012
http://dx.doi.org/10.1101/gr.220533.117

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