Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity

DNA base damage is an important contributor to genome instability, but how the formation and repair of these lesions is affected by the genomic landscape and contributes to mutagenesis is unknown. Here, we describe genome-wide maps of DNA base damage, repair, and mutagenesis at single nucleotide res...

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Detalles Bibliográficos
Autores principales: Mao, Peng, Brown, Alexander J., Malc, Ewa P., Mieczkowski, Piotr A., Smerdon, Michael J., Roberts, Steven A., Wyrick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630031/
https://www.ncbi.nlm.nih.gov/pubmed/28912372
http://dx.doi.org/10.1101/gr.225771.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630031/
https://www.ncbi.nlm.nih.gov/pubmed/28912372
http://dx.doi.org/10.1101/gr.225771.117

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