Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants

The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD). In order to identify additional AD risk genes, we performed targeted sequencing and rare variant burden association s...

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Detalles Bibliográficos
Autores principales: Rehker, Jan, Rodhe, Johanna, Nesbitt, Ryan R., Boyle, Evan A., Martin, Beth K., Lord, Jenny, Karaca, Ilker, Naj, Adam, Jessen, Frank, Helisalmi, Seppo, Soininen, Hilkka, Hiltunen, Mikko, Ramirez, Alfredo, Scherer, Martin, Farrer, Lindsay A., Haines, Jonathan L., Pericak-Vance, Margaret A., Raskind, Wendy H., Cruchaga, Carlos, Schellenberg, Gerard D., Joseph, Bertrand, Brkanac, Zoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630132/
https://www.ncbi.nlm.nih.gov/pubmed/28985224
http://dx.doi.org/10.1371/journal.pone.0185777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630132/
https://www.ncbi.nlm.nih.gov/pubmed/28985224
http://dx.doi.org/10.1371/journal.pone.0185777

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