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Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity

Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when cap-dependent translation is inhibited. IRES stru...

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Detalles Bibliográficos
Autores principales: Gritsenko, Alexey A., Weingarten-Gabbay, Shira, Elias-Kirma, Shani, Nir, Ronit, de Ridder, Dick, Segal, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630158/
https://www.ncbi.nlm.nih.gov/pubmed/28922394
http://dx.doi.org/10.1371/journal.pcbi.1005734