Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk

The extent to which genetic influences on cardiovascular disease risk are mediated by changes in DNA methylation levels has not been systematically explored. We developed an analytical framework that integrates genetic fine mapping and Mendelian randomization with epigenome-wide association studies...

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Detalles Bibliográficos
Autores principales: Richardson, Tom G., Zheng, Jie, Davey Smith, George, Timpson, Nicholas J., Gaunt, Tom R., Relton, Caroline L., Hemani, Gibran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630190/
https://www.ncbi.nlm.nih.gov/pubmed/28985495
http://dx.doi.org/10.1016/j.ajhg.2017.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630190/
https://www.ncbi.nlm.nih.gov/pubmed/28985495
http://dx.doi.org/10.1016/j.ajhg.2017.09.003

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