Cargando…

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk

The extent to which genetic influences on cardiovascular disease risk are mediated by changes in DNA methylation levels has not been systematically explored. We developed an analytical framework that integrates genetic fine mapping and Mendelian randomization with epigenome-wide association studies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Tom G., Zheng, Jie, Davey Smith, George, Timpson, Nicholas J., Gaunt, Tom R., Relton, Caroline L., Hemani, Gibran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630190/ https://www.ncbi.nlm.nih.gov/pubmed/28985495 http://dx.doi.org/10.1016/j.ajhg.2017.09.003

Ejemplares similares

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease
por: Richardson, Tom G, et al.
Publicado: (2018)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
por: Taylor, Kurt, et al.
Publicado: (2019)

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
por: Battram, Thomas, et al.
Publicado: (2022)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
por: Fang, Si, et al.
Publicado: (2022)

Identifying fenofibrate responsive CpG sites
por: Cantor, Rita, et al.
Publicado: (2018)

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility
por: Richardson, Tom G, et al.
Publicado: (2019)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
por: Richardson, Tom G, et al.
Publicado: (2019)

Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes
por: Yu, Fangtang, et al.
Publicado: (2020)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects
por: Zaghlool, Shaza B., et al.
Publicado: (2016)

In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size
por: Shyamala, Nivas, et al.
Publicado: (2022)

Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes
por: Galván, Silvia C, et al.
Publicado: (2011)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Evaluating the potential role of pleiotropy in Mendelian randomization studies
por: Hemani, Gibran, et al.
Publicado: (2018)

CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?
por: Han, Leng, et al.
Publicado: (2009)

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
por: Grandi, Fiorella C., et al.
Publicado: (2015)

CpG Methylation in Aging: Trajectories of Individual Sites
por: Meer, Margarita, et al.
Publicado: (2020)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content
por: Mugal, Carina F, et al.
Publicado: (2011)

Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites
por: Wang, Zi-yue, et al.
Publicado: (2017)

Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination
por: Cannistraro, Vincent J., et al.
Publicado: (2010)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Correction: Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites
por: Wang, Zi-yue, et al.
Publicado: (2018)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

Mutation saturation for fitness effects at human CpG sites
por: Agarwal, Ipsita, et al.
Publicado: (2021)

Epigenetic inheritance is unfaithful at intermediately methylated CpG sites
por: Hay, Amir D., et al.
Publicado: (2023)

Multiomics Data Analysis Identified CpG Sites That Mediate the Impact of Smoking on Cardiometabolic Traits
por: Nikpay, Majid
Publicado: (2023)

Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?
por: Bowden, Jack, et al.
Publicado: (2018)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

Putative Zinc Finger Protein Binding Sites Are Over-Represented in the Boundaries of Methylation-Resistant CpG Islands in the Human Genome
por: Fan, Shicai, et al.
Publicado: (2007)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
por: Borges, Maria-Carolina, et al.
Publicado: (2022)

Epigenetic age-predictor for mice based on three CpG sites
por: Han, Yang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k91gdkrsnn5mjrqgdopl43dcob