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p53 upregulates PLCε-IP3-Ca(2+) pathway and inhibits autophagy through its target gene Rap2B
The tumor suppressor p53 plays a pivotal role in numerous cellular responses as it regulates cell proliferation, metabolism, cellular growth, and autophagy. In order to identify novel p53 target genes, we utilized an unbiased microarray approach and identified Rap2B as a robust candidate, which belo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630284/ https://www.ncbi.nlm.nih.gov/pubmed/29029384 http://dx.doi.org/10.18632/oncotarget.18112 |