Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential activation of Notch...

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Detalles Bibliográficos
Autores principales: Bayin, N. Sumru, Frenster, Joshua D., Sen, Rajeev, Si, Sheng, Modrek, Aram S., Galifianakis, Nataliya, Dolgalev, Igor, Ortenzi, Valerio, Illa-Bochaca, Irineu, Khahera, Anadjeet, Serrano, Jonathan, Chiriboga, Luis, Zagzag, David, Golfinos, John G., Doyle, Werner, Tsirigos, Aristotelis, Heguy, Adriana, Chesler, Mitch, Barcellos-Hoff, Mary Helen, Snuderl, Matija, Placantonakis, Dimitris G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630302/
https://www.ncbi.nlm.nih.gov/pubmed/29029402
http://dx.doi.org/10.18632/oncotarget.18117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630302/
https://www.ncbi.nlm.nih.gov/pubmed/29029402
http://dx.doi.org/10.18632/oncotarget.18117

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