Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL

The Fip1-like1 (FIP1L1)–platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation. In this study, we investigate the mechanism of F/P in collaboration with IL-5 in CEL. The results showed that Lyn, a...

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Detalles Bibliográficos
Autores principales: Li, Bin, Zhang, Guangsen, Li, Cui, Li, Ruijuan, Lu, Jingchen, He, Zhengxi, Wang, Quan, Peng, Zhenzi, Wang, Jun, Dong, Yeping, Zhang, Chunfang, Tan, Jie Qiong, Bahri, Nacef, Wang, Yuexiang, Duan, Chaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630306/
https://www.ncbi.nlm.nih.gov/pubmed/29029406
http://dx.doi.org/10.18632/oncotarget.11401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630306/
https://www.ncbi.nlm.nih.gov/pubmed/29029406
http://dx.doi.org/10.18632/oncotarget.11401

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