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Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL
The Fip1-like1 (FIP1L1)–platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation. In this study, we investigate the mechanism of F/P in collaboration with IL-5 in CEL. The results showed that Lyn, a...
Autors principals: | , , , , , , , , , , , , , , |
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Format: | Online Article Text |
Idioma: | English |
Publicat: |
Impact Journals LLC
2016
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Matèries: | |
Accés en línia: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630306/ https://www.ncbi.nlm.nih.gov/pubmed/29029406 http://dx.doi.org/10.18632/oncotarget.11401 |