Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation

Anthrax lethal toxin is a typical A-B type protein toxin secreted by Bacillus anthracis. Lethal factor (LF) is the catalytic A-subunit, a metalloprotease having MEKs as targets. LF relies on the cell-binding B-subunit, protective antigen (PA), to gain entry into the cytosol of target cells. PA binds...

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Detalles Bibliográficos
Autores principales: Liu, Shihui, Ma, Qian, Fattah, Rasem, Bugge, Thomas H., Leppla, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630317/
https://www.ncbi.nlm.nih.gov/pubmed/29029417
http://dx.doi.org/10.18632/oncotarget.17729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630317/
https://www.ncbi.nlm.nih.gov/pubmed/29029417
http://dx.doi.org/10.18632/oncotarget.17729

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