7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway

Hypercholesterolemia is one of the risk factors for poor outcome in breast cancer therapy. To elucidate the influence of the main circulating oxysterols, cholesterol oxidation products, on the cell-killing effect of doxorubicin, cells were exposed to oxysterols at a subtoxic concentration. When cell...

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Detalles Bibliográficos
Autores principales: Wang, Chun-Wei, Huang, Chiung-Chiao, Chou, Pei-Hsin, Chang, Yu-Ping, Wei, Shouzuo, Guengerich, Frederick Peter, Chou, Yueh-Ching, Wang, Sheng-Fan, Lai, Ping-Shan, Souček, Pavel, Ueng, Yune-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630390/
https://www.ncbi.nlm.nih.gov/pubmed/29029490
http://dx.doi.org/10.18632/oncotarget.19789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630390/
https://www.ncbi.nlm.nih.gov/pubmed/29029490
http://dx.doi.org/10.18632/oncotarget.19789

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