The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity dur...

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Detalles Bibliográficos
Autores principales: Hosokawa, Kentaro, MacArthur, Ben D., Ikushima, Yoshiko Matsumoto, Toyama, Hirofumi, Masuhiro, Yoshikazu, Hanazawa, Shigemasa, Suda, Toshio, Arai, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630588/
https://www.ncbi.nlm.nih.gov/pubmed/28986560
http://dx.doi.org/10.1038/s41467-017-00935-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630588/
https://www.ncbi.nlm.nih.gov/pubmed/28986560
http://dx.doi.org/10.1038/s41467-017-00935-4

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