Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria

Bik reduces hyperplastic epithelial cells by releasing calcium from endoplasmic reticulum stores and causing apoptosis, but the detailed mechanisms are not known. Here we report that Bik dissociates the Bak/Bcl-2 complex to enrich for ER-associated Bak and interacts with the kinase domain of DAPk1 t...

Descripción completa

Detalles Bibliográficos
Autores principales: Mebratu, Yohannes A., Leyva-Baca, Ivan, Wathelet, Marc G., Lacey, Neal, Chand, Hitendra S., Choi, Augustine M. K., Tesfaigzi, Yohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630627/
https://www.ncbi.nlm.nih.gov/pubmed/28986568
http://dx.doi.org/10.1038/s41467-017-00975-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630627/
https://www.ncbi.nlm.nih.gov/pubmed/28986568
http://dx.doi.org/10.1038/s41467-017-00975-w

Ejemplares similares