Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site

We have synthesized a series of new β-lactam-azide derivatives as orally active anti-tumor agents by targeting tubulin colchicine binding site and examined their structure activity relationship (SAR). Among them, compound 28 exhibited the most potent antiproliferative activity against MGC-803 cells...

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Detalles Bibliográficos
Autores principales: Fu, Dong-Jun, Fu, Ling, Liu, Ying-Chao, Wang, Jun-Wei, Wang, Yu-Qing, Han, Bing-Kai, Li, Xiao-Rui, Zhang, Chuang, Li, Feng, Song, Jian, Zhao, Bing, Mao, Ruo-Wang, Zhao, Ruo-Han, Zhang, Sai-Yang, Zhang, Li, Zhang, Yan-Bing, Liu, Hong-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630639/
https://www.ncbi.nlm.nih.gov/pubmed/28986548
http://dx.doi.org/10.1038/s41598-017-12912-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630639/
https://www.ncbi.nlm.nih.gov/pubmed/28986548
http://dx.doi.org/10.1038/s41598-017-12912-4

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