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Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis
BACKGROUND: APX001 is a first-in-class intravenous and orally available broad spectrum antifungal inhibitor of Gwt1, a protein involved in glycosylphosphatidylinositol anchor biosynthesis. This study evaluated efficacy of APX001, alone and in combination with fluconazole (FCN), in a mouse model of c...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630770/ http://dx.doi.org/10.1093/ofid/ofx163.1225 |