Discovery of a Series of Potent and Selective Nucleotide Prodrug Inhibitors of Respiratory Syncytial Virus (RSV) Replication

BACKGROUND: RSV can cause severe respiratory tract infections in infants and the elderly. Current experimental therapies include polymerase and fusion inhibitors, but their clinical use may be limited by toxicity or rapid emergence of viral resistance. Here we report new nucleotide prodrugs that are...

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Detalles Bibliográficos
Autores principales: Good, Steven, Moussa, Adel, Meillon, Jean-Cristophe, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631159/
http://dx.doi.org/10.1093/ofid/ofx163.1222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631159/
http://dx.doi.org/10.1093/ofid/ofx163.1222

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