Pharmacokinetics (PK) and Safety of Intravenous (IV) Brincidofovir (BCV) in Healthy Adult Subjects

BACKGROUND: BCV is a lipid conjugate nucleotide that has shown rapid viral clearance in patients with adenovirus infection and improved survival in animal models of smallpox. In preclinical studies in rats, IV BCV dosed twice weekly for up to 29 days was not associated with gastrointestinal (GI), he...

Descripción completa

Detalles Bibliográficos
Autores principales: Wire, Mary Beth, Morrison, Marion, Anderson, Maggie, Arumugham, Thangam, Dunn, John, Naderer, Odin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631843/
http://dx.doi.org/10.1093/ofid/ofx163.725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631843/
http://dx.doi.org/10.1093/ofid/ofx163.725

Ejemplares similares