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Picomolar inhibition of β-galactosidase (bovine liver) attributed to loop closure
In an effort to examine similarities in the active sites of glycosidases within the GH35 family, we performed a structure-activity-relationship study using our recently described library of galactonoamidines. The kinetic evaluation based on UV/Vis spectroscopy disclosed inhibition of β-galactosidase...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632213/ https://www.ncbi.nlm.nih.gov/pubmed/28844803 http://dx.doi.org/10.1016/j.bmc.2017.07.020 |