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Picomolar inhibition of β-galactosidase (bovine liver) attributed to loop closure

In an effort to examine similarities in the active sites of glycosidases within the GH35 family, we performed a structure-activity-relationship study using our recently described library of galactonoamidines. The kinetic evaluation based on UV/Vis spectroscopy disclosed inhibition of β-galactosidase...

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Detalles Bibliográficos
Autores principales: Pickens, Jessica B., Wang, Feng, Striegler, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632213/
https://www.ncbi.nlm.nih.gov/pubmed/28844803
http://dx.doi.org/10.1016/j.bmc.2017.07.020

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