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P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

BACKGROUND: Major depressive disorder is characterized by structural and functional abnormalities of cortical and limbic brain areas, including a decrease in spine synapse number in the dentate gyrus of the hippocampus. Recent studies highlighted that both genetic and pharmacological invalidation of...

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Detalles Bibliográficos
Autores principales: Otrokocsi, Lilla, Kittel, Ágnes, Sperlágh, Beáta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632310/
https://www.ncbi.nlm.nih.gov/pubmed/28633291
http://dx.doi.org/10.1093/ijnp/pyx046