Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts

Abundance of proline (Pro) in collagen molecule led us to investigate whether Pro supply affects collagen biosynthesis in human skin fibroblasts. Treatment of the cells with milimolar concentrations (5 and 10 mM) of Pro for 24 and 48 h contributed to increase in α(1) subunit of collagen type I (COL1...

Descripción completa

Detalles Bibliográficos
Autores principales: Szoka, Lukasz, Karna, Ewa, Hlebowicz-Sarat, Kornelia, Karaszewski, Jacek, Palka, Jerzy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632346/
https://www.ncbi.nlm.nih.gov/pubmed/28526934
http://dx.doi.org/10.1007/s11010-017-3069-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632346/
https://www.ncbi.nlm.nih.gov/pubmed/28526934
http://dx.doi.org/10.1007/s11010-017-3069-y

Ejemplares similares