Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages

TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) indu...

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Detalles Bibliográficos
Autores principales: Ehrnström, Birgitta, Beckwith, Kai Sandvold, Yurchenko, Mariia, Moen, Siv Helen, Kojen, June Frengen, Lentini, Germana, Teti, Giuseppe, Damås, Jan Kristian, Espevik, Terje, Stenvik, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632357/
https://www.ncbi.nlm.nih.gov/pubmed/29042860
http://dx.doi.org/10.3389/fimmu.2017.01243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632357/
https://www.ncbi.nlm.nih.gov/pubmed/29042860
http://dx.doi.org/10.3389/fimmu.2017.01243

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