Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia. Pharmacological management of arrhythmia associated with QT prolongation is...

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Detalles Bibliográficos
Autores principales: Colman, Michael A., Perez Alday, Erick A., Holden, Arun V., Benson, Alan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632683/
https://www.ncbi.nlm.nih.gov/pubmed/29046643
http://dx.doi.org/10.3389/fphys.2017.00757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632683/
https://www.ncbi.nlm.nih.gov/pubmed/29046643
http://dx.doi.org/10.3389/fphys.2017.00757

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