Computational Cardiac Modeling Reveals Mechanisms of Ventricular Arrhythmogenesis in Long QT Syndrome Type 8: CACNA1C R858H Mutation Linked to Ventricular Fibrillation

Functional analysis of the L-type calcium channel has shown that the CACNA1C R858H mutation associated with severe QT interval prolongation may lead to ventricular fibrillation (VF). This study investigated multiple potential mechanisms by which the CACNA1C R858H mutation facilitates and perpetuates...

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Detalles Bibliográficos
Autores principales: Bai, Jieyun, Wang, Kuanquan, Liu, Yashu, Li, Yacong, Liang, Cuiping, Luo, Gongning, Dong, Suyu, Yuan, Yongfeng, Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632762/
https://www.ncbi.nlm.nih.gov/pubmed/29046645
http://dx.doi.org/10.3389/fphys.2017.00771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632762/
https://www.ncbi.nlm.nih.gov/pubmed/29046645
http://dx.doi.org/10.3389/fphys.2017.00771

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