Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways

Senescence is a crucial driver of intervertebral disc degeneration (IDD). Disc cells are exposed to high oxygen tension due to neovascularization in degenerative discs. However, the effect of oxygen tension on disc cell senescence was unknown. Herein, rat nucleus pulposus (NP) cells were cultured un...

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Detalles Bibliográficos
Autores principales: Feng, Chencheng, Zhang, Yang, Yang, Minghui, Lan, Minghong, Liu, Huan, Huang, Bo, Zhou, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632907/
https://www.ncbi.nlm.nih.gov/pubmed/29147462
http://dx.doi.org/10.1155/2017/7426458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632907/
https://www.ncbi.nlm.nih.gov/pubmed/29147462
http://dx.doi.org/10.1155/2017/7426458

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