Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhat, Shreyas, Hasenhuetl, Peter S., Kasture, Ameya, El-Kasaby, Ali, Baumann, Michael H., Blough, Bruce E., Sucic, Sonja, Sandtner, Walter, Freissmuth, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633137/
https://www.ncbi.nlm.nih.gov/pubmed/28842491
http://dx.doi.org/10.1074/jbc.M117.794081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633137/
https://www.ncbi.nlm.nih.gov/pubmed/28842491
http://dx.doi.org/10.1074/jbc.M117.794081

Ejemplares similares