Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice

We investigated a series of Tween 85 modified low molecular weight polyethylenimine (LPEI, 0.8k/1.2k/2.0k)-copolymers (Zs) through simple formulation and covalent conjugation with phosphorodiamidate morpholino oligomer (PMO) for their potential to enhance delivery in vitro and in dystrophic mdx mice...

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Detalles Bibliográficos
Autores principales: Wang, Mingxing, Wu, Bo, Tucker, Jason D., Shah, Sapana N., Lu, Peijuan, Bollinger, Lauren E., Lu, Qilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633364/
https://www.ncbi.nlm.nih.gov/pubmed/29246291
http://dx.doi.org/10.1016/j.omtn.2017.09.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633364/
https://www.ncbi.nlm.nih.gov/pubmed/29246291
http://dx.doi.org/10.1016/j.omtn.2017.09.006

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