Increased LOH Due to Defective Sister Chromatid Cohesion Is Due Primarily to Chromosomal Aneuploidy and Not Recombination

Loss of heterozygosity (LOH) is an important factor in cancer, pathogenic fungi, and adaptation to changing environments. The sister chromatid cohesion process (SCC) suppresses aneuploidy and therefore whole chromosome LOH. SCC is also important to channel recombinational repair to sister chromatids...

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Detalles Bibliográficos
Autores principales: Sagi, Dror, Marcos-Hadad, Evgeniya, Bari, Vinay K., Resnick, Michael A., Covo, Shay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633381/
https://www.ncbi.nlm.nih.gov/pubmed/28983067
http://dx.doi.org/10.1534/g3.117.300091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633381/
https://www.ncbi.nlm.nih.gov/pubmed/28983067
http://dx.doi.org/10.1534/g3.117.300091

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