Cargando…
PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients
Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in Alzheimer type dementia can be found in peripheral tissues. We have previously sh...
Autores principales: | Salech, Felipe, Ponce, Daniela P., SanMartín, Carol D., Rogers, Nicole K., Chacón, Carlos, Henríquez, Mauricio, Behrens, Maria I. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633596/ https://www.ncbi.nlm.nih.gov/pubmed/29051731 http://dx.doi.org/10.3389/fnagi.2017.00310 |
Ejemplares similares
-
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease
por: Salech, Felipe, et al.
Publicado: (2018) -
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease
por: Salech, Felipe, et al.
Publicado: (2020) -
The paradox of opposite directions of gene expressions in MCI and AD suggests possible therapy to prevent progression of MCI to AD
por: Fessel, Jeffrey
Publicado: (2020) -
Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
por: Salech, Felipe, et al.
Publicado: (2022) -
Cancer History Avoids the Increase of Senescence Markers in Peripheral Cells of Amnestic Mild Cognitive Impaired Patients
por: SanMartín, Carol D., et al.
Publicado: (2023)