Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice

The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity whi...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Shui, Fengchun, Liu, Cheng, Zhou, Xinbo, Li, Wei, Zheng, Zhibing, Fu, Wei, Wang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633609/
https://www.ncbi.nlm.nih.gov/pubmed/29051736
http://dx.doi.org/10.3389/fphar.2017.00707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633609/
https://www.ncbi.nlm.nih.gov/pubmed/29051736
http://dx.doi.org/10.3389/fphar.2017.00707

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