Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study

BACKGROUND: The relationship of alteration of metabolic syndrome (MetS) with dementia remains unclear. The purpose of study was to evaluate the association between dynamic change in MetS status around a 5‐year period and dementia. METHODS AND RESULTS: The cohort study was conducted from the Taiwanes...

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Autores principales: Fan, Yen‐Chun, Chou, Chia‐Chi, You, San‐Lin, Sun, Chien‐An, Chen, Chien‐Jen, Bai, Chyi‐Huey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634246/
https://www.ncbi.nlm.nih.gov/pubmed/28899896
http://dx.doi.org/10.1161/JAHA.116.004749
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author Fan, Yen‐Chun
Chou, Chia‐Chi
You, San‐Lin
Sun, Chien‐An
Chen, Chien‐Jen
Bai, Chyi‐Huey
author_facet Fan, Yen‐Chun
Chou, Chia‐Chi
You, San‐Lin
Sun, Chien‐An
Chen, Chien‐Jen
Bai, Chyi‐Huey
author_sort Fan, Yen‐Chun
collection PubMed
description BACKGROUND: The relationship of alteration of metabolic syndrome (MetS) with dementia remains unclear. The purpose of study was to evaluate the association between dynamic change in MetS status around a 5‐year period and dementia. METHODS AND RESULTS: The cohort study was conducted from the Taiwanese Survey on Prevalence of Hypertension, Hyperglycemia, and Hyperlipidemia in 2002, with follow‐up in 2007. The sample was subsequently linked to the National Health Insurance Research Database. Participants were divided into 3 groups: persistent MetS (MetS both in 2002 and 2007); nonpersistent MetS (MetS either in 2002 or 2007); and non‐MetS (MetS neither in 2002 nor 2007). Furthermore, the individuals with nonpersistent MetS were categorized as improved MetS (MetS in 2002 but not in 2007) and worsened MetS (MetS not in 2002 but in 2007). Each participant was tracked until the end of 2011 to identify the development of dementia. In total, 3458 participants aged 40 to 80 years were included. Up to 10 years and 31 741 person‐years of follow‐up, 76 patients developed dementia. Only a relationship was found between the nonpersistent MetS and dementia (adjusted hazard ratio=1.93; 95% confidence interval =1.17–3.19; P=0.010). Moreover, a significantly higher dementia risk was observed in patients with worsened MetS (adjusted hazard ratio=2.22; 95% confidence interval=1.32–3.72; P=0.003), but not those with persistent (P=0.752) or improved (P=0.829) MetS. Similar results were detected in participants aged ≥65 years. CONCLUSIONS: Patients with worsened MetS had an increased dementia risk during the 10‐year follow‐up period in a population‐based sample.
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spelling pubmed-56342462017-10-18 Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study Fan, Yen‐Chun Chou, Chia‐Chi You, San‐Lin Sun, Chien‐An Chen, Chien‐Jen Bai, Chyi‐Huey J Am Heart Assoc Original Research BACKGROUND: The relationship of alteration of metabolic syndrome (MetS) with dementia remains unclear. The purpose of study was to evaluate the association between dynamic change in MetS status around a 5‐year period and dementia. METHODS AND RESULTS: The cohort study was conducted from the Taiwanese Survey on Prevalence of Hypertension, Hyperglycemia, and Hyperlipidemia in 2002, with follow‐up in 2007. The sample was subsequently linked to the National Health Insurance Research Database. Participants were divided into 3 groups: persistent MetS (MetS both in 2002 and 2007); nonpersistent MetS (MetS either in 2002 or 2007); and non‐MetS (MetS neither in 2002 nor 2007). Furthermore, the individuals with nonpersistent MetS were categorized as improved MetS (MetS in 2002 but not in 2007) and worsened MetS (MetS not in 2002 but in 2007). Each participant was tracked until the end of 2011 to identify the development of dementia. In total, 3458 participants aged 40 to 80 years were included. Up to 10 years and 31 741 person‐years of follow‐up, 76 patients developed dementia. Only a relationship was found between the nonpersistent MetS and dementia (adjusted hazard ratio=1.93; 95% confidence interval =1.17–3.19; P=0.010). Moreover, a significantly higher dementia risk was observed in patients with worsened MetS (adjusted hazard ratio=2.22; 95% confidence interval=1.32–3.72; P=0.003), but not those with persistent (P=0.752) or improved (P=0.829) MetS. Similar results were detected in participants aged ≥65 years. CONCLUSIONS: Patients with worsened MetS had an increased dementia risk during the 10‐year follow‐up period in a population‐based sample. John Wiley and Sons Inc. 2017-09-12 /pmc/articles/PMC5634246/ /pubmed/28899896 http://dx.doi.org/10.1161/JAHA.116.004749 Text en © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Fan, Yen‐Chun
Chou, Chia‐Chi
You, San‐Lin
Sun, Chien‐An
Chen, Chien‐Jen
Bai, Chyi‐Huey
Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title_full Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title_fullStr Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title_full_unstemmed Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title_short Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study
title_sort impact of worsened metabolic syndrome on the risk of dementia: a nationwide cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634246/
https://www.ncbi.nlm.nih.gov/pubmed/28899896
http://dx.doi.org/10.1161/JAHA.116.004749
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