The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

BACKGROUND: Heterozygous loss of function mutations in the KCNK3 gene cause hereditary pulmonary arterial hypertension (PAH). KCNK3 encodes an acid‐sensitive potassium channel, which contributes to the resting potential of human pulmonary artery smooth muscle cells. KCNK3 is widely expressed in the...

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Detalles Bibliográficos
Autores principales: Bohnen, Michael S., Roman‐Campos, Danilo, Terrenoire, Cecile, Jnani, Jack, Sampson, Kevin J., Chung, Wendy K., Kass, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634293/
https://www.ncbi.nlm.nih.gov/pubmed/28889099
http://dx.doi.org/10.1161/JAHA.117.006465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634293/
https://www.ncbi.nlm.nih.gov/pubmed/28889099
http://dx.doi.org/10.1161/JAHA.117.006465

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