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Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the β-globin LCR
Transcription factors play roles in gene transcription through direct binding to their motifs in genome, and inhibiting this binding provides an effective strategy for studying their roles. Here, we applied the CRISPR (clustered, regularly interspaced, short palindromic repeat)/spCas9 (CRISPR-associ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634328/ https://www.ncbi.nlm.nih.gov/pubmed/28729249 http://dx.doi.org/10.1042/BSR20170976 |