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Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the β-globin LCR

Transcription factors play roles in gene transcription through direct binding to their motifs in genome, and inhibiting this binding provides an effective strategy for studying their roles. Here, we applied the CRISPR (clustered, regularly interspaced, short palindromic repeat)/spCas9 (CRISPR-associ...

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Detalles Bibliográficos
Autores principales: Kim, Yea Woon, Kim, AeRi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634328/
https://www.ncbi.nlm.nih.gov/pubmed/28729249
http://dx.doi.org/10.1042/BSR20170976