Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes

[Image: see text] We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au...

Descripción completa

Detalles Bibliográficos
Autores principales: Ebule, Rene, Liang, Shengzong, Hammond, Gerald B., Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634393/
https://www.ncbi.nlm.nih.gov/pubmed/29034119
http://dx.doi.org/10.1021/acscatal.7b02567
_version_ 1783270081835302912
author Ebule, Rene
Liang, Shengzong
Hammond, Gerald B.
Xu, Bo
author_facet Ebule, Rene
Liang, Shengzong
Hammond, Gerald B.
Xu, Bo
author_sort Ebule, Rene
collection PubMed
description [Image: see text] We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au–Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.
format Online
Article
Text
id pubmed-5634393
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-56343932018-09-07 Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes Ebule, Rene Liang, Shengzong Hammond, Gerald B. Xu, Bo ACS Catal [Image: see text] We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au–Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air. American Chemical Society 2017-09-07 2017-10-06 /pmc/articles/PMC5634393/ /pubmed/29034119 http://dx.doi.org/10.1021/acscatal.7b02567 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ebule, Rene
Liang, Shengzong
Hammond, Gerald B.
Xu, Bo
Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title_full Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title_fullStr Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title_full_unstemmed Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title_short Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
title_sort chloride-tolerant gold(i)-catalyzed regioselective hydrochlorination of alkynes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634393/
https://www.ncbi.nlm.nih.gov/pubmed/29034119
http://dx.doi.org/10.1021/acscatal.7b02567
work_keys_str_mv AT ebulerene chloridetolerantgoldicatalyzedregioselectivehydrochlorinationofalkynes
AT liangshengzong chloridetolerantgoldicatalyzedregioselectivehydrochlorinationofalkynes
AT hammondgeraldb chloridetolerantgoldicatalyzedregioselectivehydrochlorinationofalkynes
AT xubo chloridetolerantgoldicatalyzedregioselectivehydrochlorinationofalkynes

Ejemplares similares