Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway. By solving the crystal structure of the IL-1α/apta...

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Detalles Bibliográficos
Autores principales: Ren, Xiaoming, Gelinas, Amy D., von Carlowitz, Ira, Janjic, Nebojsa, Pyle, Anna Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634487/
https://www.ncbi.nlm.nih.gov/pubmed/28993621
http://dx.doi.org/10.1038/s41467-017-00864-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634487/
https://www.ncbi.nlm.nih.gov/pubmed/28993621
http://dx.doi.org/10.1038/s41467-017-00864-2

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